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Neozine Cream 500gm
- Topical Prophylaxis: Prevents bacterial colonization and infection in burn wounds.
- Topical Antibacterial Management: Manages contamination or infection-prone wounds, excluding burns.
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✅ Description:
- Skin infection occurs when skin is broken, allowing microorganisms to invade tissues, triggering inflammation and slowing healing.
- Burns damage skin or deeper tissues due to heat, electricity, or chemicals.
- Bacterial infection arises from harmful bacteria growth, causing illness; bacteria can be gram-positive or gram-negative.
Silver Sulphadiazine 1% Cream is indicated for the prevention and treatment of infections during burn treatment. Additionally, it serves as an antiseptic for minor cuts and abrasions. By eliminating infectious microorganisms, it alleviates inflammation symptoms like burning sensation, irritation, and pain, thus facilitating the healing process of burns and wounds. It's important to adhere to the doctor's instructions for optimal results.
Safety Advices
Alcohol
UNSAFE
The interaction of SILVER SULFADIAZINE with alcohol is unknown. Please consult a doctor before consuming alcohol while using SILVER SULFADIAZINE.
Pregnancy
CONSULT YOUR DOCTOR
Limited information is available on how SILVER SULFADIAZINE affects pregnancy. Consult a doctor if you are pregnant before using SILVER SULFADIAZINE.
Breastfeeding
CONSULT YOUR DOCTOR
Consult your doctor before using SILVER SULFADIAZINE if you are breastfeeding. However, if you need to apply SILVER SULFADIAZINE to your breasts, avoid doing so shortly before feeding your baby.
Driving
SAFE
SILVER SULFADIAZINE is generally safe to use before driving. However, if you experience side effects like dizziness or burning sensation in the affected areas, refrain from driving and operating machinery until you feel better.
Kidney
CONSULT YOUR DOCTOR
Inform your doctor if you have any history of liver diseases before using SILVER SULFADIAZINE.
Liver
CONSULT YOUR DOCTOR
Inform your doctor if you have any history of kidney diseases before using SILVER SULFADIAZINE.
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✔️ Pharmacology of Neozine Cream
- Mechanism: Structural changes in bacterial cell membrane after drug exposure.
- Action: Weakens cell wall, and reduces viability in sensitive strains.
- Silver Moiety: Binds to bacterial cells, attaches to DNA, and prevents cell proliferation.
- Sulfadiazine Moiety: Provides bacteriostatic action against sensitive organisms.
- Absorption: Up to 10% absorbed in adults, 60 to 85% excreted in urine.
✔️ Side Effects of Neozine Cream
- Transient leukopenia reported.
- Skin necrosis, erythema multiforme, skin discoloration, burning sensation, rashes, and interstitial nephritis are possible.
✔️ Suggestions:
- Caution is advised in individuals with significant hepatic or renal impairment, or if porphyria is suspected.
- Patients known to be sensitive to systemic sulphonamides should use the cream cautiously.
- Caution is necessary in individuals with glucose-6-phosphate dehydrogenase deficiency.
- Concurrent use with topical proteolytic enzymes should be approached with caution.
- The application of silver sulfadiazine cream may delay the separation of burn eschar and alter the appearance of burn wounds.
- Regarding lactation, it is not known if the cream is distributed into breast milk, so caution is advised.
✔️ Administration & Dosage of Neozine Cream
- Cleanse burn wounds before application.
- Apply once to twice daily, 1/16 inches thick.
- Reapply after hydrotherapy.
- Continue until healing or ready for grafting.
✔️ Interaction of Neozine Cream
- Enzymatic Debriding Agents: May inactivate them.
- Oral Hypoglycemic Agents/Phenytoin: Levels may be potentiated in large-area burns.
- Cimetidine: May increase leukopenia incidence.
✔️ Contraindications of Neozine Cream
- Hypersensitivity to ingredients.
- Not for pregnant women at term, premature infants, or newborns in the first two months.
✔️ Pregnancy & Lactation:
- Category B: Use if clearly justified in pregnancy.
- Not known if excreted in human milk. Consider risk-benefit in nursing mothers.
✔️ Precautions & Warnings:
- Monitor hepatic and renal functions.
- Caution with topical proteolytic enzymes.
- Monitor serum sulfa concentrations in extensive burn wounds.
✔️ Storage Conditions:
- Below 30°C, away from light and moisture.
- Keep out of children's reach.
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